Prolozone therapy is an alternative, nonsurgical treatment that may be used for all forms of musculoskeletal and joint pain. It involves injection therapy of collagen-producing substances and ozone gas into the patient’s connective tissue. Such injections have been shown to result in the reconstruction of damaged tissue. Prolozone therapy is an improvement over traditional prolotherapy because of its use of ozone, a substance that stimulates the body’s ability to repair joints. Prolozone is used more commonly in Europe than in the Pakistan. Prolozone has been shown to have a very high rate of success in permanently relieving chronic pain. It is also sometimes used as an alternative treatment for a wide variety of conditions, including diabetes, heart disease, Parkinson’s disease, macular degeneration, cancer, and even dental problems.